Over-expression of mutant copper, zinc superoxide dismutase (SOD) in mice induces ALS and has become the most widely used model of neurodegeneration.However, no pharmaceutical agent in 20 years has extended lifespan by more than a few weeks.The Copper-Chaperone-for-SOD (CCS) protein completes the maturation of SOD by inserting copper, but paradoxic
This article explores Mugs/Cups/Tumblers the relations among three forms of representations (artistic, mental, and neural) and immersion, considered as an altered state of consciousness, in the context of literary reading.We first define immersive reading as an intensification of our embodied experience of literary representation, in accordance to
The immune system is remarkably Pet Bowl responsive to a myriad of invading microorganisms and provides continuous surveillance against tissue damage and developing tumor cells.To achieve these diverse functions, multiple soluble and cellular components must react in an orchestrated cascade of events to control the specificity, magnitude and persis
Gilles de la Tourette syndrome (GTS) is a neurodevelopmental disorder characterized by motor and vocal tics.Hyperactivity of dopaminergic transmission is considered a prime abnormality in the pathophysiology of tics.There are reciprocal antagonistic interactions between adenosine and dopamine transmission.The aim of the study was to analyze the ass
The primary cilium is a sensory organelle, defects in which cause a wide range of human diseases including retinal degeneration, polycystic kidney disease and birth defects.The sensory functions of cilia require specific receptors to be targeted to the ciliary subdomain of the plasma membrane.Arf4 has been proposed to sort cargo destined for the ci